Vik Anne, Kvikstad Anne, Unsgård Geirmund, Jørgensen Jan Valentin, Torp Sverre Helge
Nevrokirurgisk avdeling, St. Olavs Hospital, 7006 Trondheim.
Tidsskr Nor Laegeforen. 2006 Sep 21;126(18):2386-7.
Extracranial metastases from meningioma are rare, and are reported to occur in less than 1 per 1000.
We report a 54-year-old man, who presented with a parasagittal meningioma with skull erosion and overlying soft tissue invasion. Tumour invading the superior sagittal sinus was not removed, and postoperative radiation was therefore delivered to the excision site. Histology was consistent with an atypical meningioma. The patient had a re-operation of a recurrence 3.5 years later, and after another year six tumours were detected close to pleura and in the lungs. A biopsy from the largest one demonstrated a metastasis having the same histology as the primary tumour.
Risk factors for metastasis of cerebral meningiomas have been suggested to be histological malignancy grade, venous sinus invasion, and local recurrences after previous craniotomy.
脑膜瘤的颅外转移罕见,据报道发生率低于千分之一。
我们报告一名54岁男性,其患有矢状窦旁脑膜瘤,伴有颅骨侵蚀和上方软组织侵犯。侵犯上矢状窦的肿瘤未被切除,因此术后对切除部位进行了放疗。组织学检查结果符合非典型脑膜瘤。该患者在3.5年后因复发接受了再次手术,又过了一年,在胸膜附近和肺部发现了六个肿瘤。对最大的一个肿瘤进行活检,结果显示转移瘤的组织学与原发肿瘤相同。
脑膜瘤转移的危险因素被认为包括组织学恶性程度分级、静脉窦侵犯以及既往开颅术后的局部复发。