Schulz B G, Müller B
Forschungslaboratorien der Schering AG, Berlin.
Eicosanoids. 1990;3(3):135-8.
In conscious Wistar rats, endothelin (ET-I) caused a dose-dependent long-lasting blood pressure increase, which was more pronounced after indomethacin pretreatment. The initial blood pressure drop was also enhanced after indomethacin. The stable prostacyclin analogue iloprost completely reversed the pressor effect of endothelin. In the hamster cheek pouch, ET-I caused a rapidly developing, long-lasting constriction of arterioles, which could be completely reversed by iloprost. The results demonstrate that prostacyclin can act as a potent functional antagonist of endothelin-induced systemic and local pressor responses.
在清醒的Wistar大鼠中，内皮素（ET-I）引起剂量依赖性的持久血压升高，吲哚美辛预处理后这种升高更为明显。吲哚美辛处理后初始血压下降也增强。稳定的前列环素类似物伊洛前列素完全逆转了内皮素的升压作用。在仓鼠颊囊，ET-I引起小动脉迅速发展的持久收缩，伊洛前列素可使其完全逆转。结果表明，前列环素可作为内皮素诱导的全身和局部升压反应的有效功能性拮抗剂。
