Pałgan Krzysztof, Dziedziczko Andrzej, Bartuzi Zbigniew
Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Katedra i Klinika Alergologii i Chorób Wewnetrznych.
Pol Merkur Lekarski. 2006 Jul;21(121):5-7.
Alternations in airway wall architecture, particularly increased smooth muscle mass are associated with pathogenesis of asthma. Muscle fiber hyperplasia and hypertrophy is a major contributor to the increase in smooth muscle mass. Airway smooth muscle was traditionally considered to have only contractile and proliferative functions and has little attention with regard to its ability to express and release inflammatory mediators. Airway smooth muscle cells have been shown to release cytokines such as: GM-CSF, IL-11, IL-6, IL-1, IL-5, IL-8, PGs and NO. Airway remodeling has been shown to respond to some degree anti-inflammatory therapy. Several study results indicate that steroid can positively influence progressive airflow limitation. Combined use of a beta2-agonist and steroid can reduced the remodeling progression.
气道壁结构的改变，尤其是平滑肌质量增加与哮喘的发病机制有关。肌纤维增生和肥大是平滑肌质量增加的主要原因。传统上认为气道平滑肌仅具有收缩和增殖功能，而对其表达和释放炎症介质的能力关注较少。气道平滑肌细胞已被证明可释放细胞因子，如：粒细胞-巨噬细胞集落刺激因子、白细胞介素-11、白细胞介素-6、白细胞介素-1、白细胞介素-5、白细胞介素-8、前列腺素和一氧化氮。已证明气道重塑在一定程度上对抗炎治疗有反应。几项研究结果表明，类固醇可对进行性气流受限产生积极影响。联合使用β2激动剂和类固醇可减缓重塑进程。
