Pattarino Franco, Giovannelli Lorella, Bellomi Sonja
DISCAFF, School of Pharmacy, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Eur J Pharm Biopharm. 2007 Feb;65(2):198-203. doi: 10.1016/j.ejpb.2006.08.007. Epub 2006 Aug 26.
The Hot Air Coating (HAC) technique was used to prepare microparticles consisting of 30% nifedipine coated with different lipid mixtures. Cetearyl alcohol or cetearyl alcohol and 5% or 15% of a poloxamer (Pluronic F68 or Pluronic F127) were used as excipients. HAC products were analyzed in terms of morphology, flowability, thermal properties and nifedipine release behaviour, in order to elucidate the role played by the Pluronics on the physico-chemical and pharmaceutical characteristics of microparticles. HAC particles were spherical and their surface appeared scale-worked; thermal studies demonstrated the existence of relevant interactions among the system components and the dissolution experiments led to the hypothesis that the drug is released primarily by diffusion through the lipid coating: the poloxamer and its concentration have a significant influence on the pharmaceutical properties of the dosage form, as shown by the a parameter of Weibull model.
采用热空气包衣（HAC）技术制备了由30%硝苯地平与不同脂质混合物包衣组成的微粒。鲸蜡硬脂醇或鲸蜡硬脂醇与5%或15%的泊洛沙姆（普朗尼克F68或普朗尼克F127）用作辅料。对HAC产品进行了形态、流动性、热性质和硝苯地平释放行为分析，以阐明泊洛沙姆对微粒物理化学和药物特性的作用。HAC颗粒呈球形，其表面呈鳞片状；热研究表明系统成分之间存在相关相互作用，溶出实验得出药物主要通过脂质包衣扩散释放的假设：如威布尔模型的a参数所示，泊洛沙姆及其浓度对剂型的药物性质有显著影响。
