通过新生儿对外周自身抗原的识别产生的CD8 +调节性T细胞。
CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen.
作者信息
Reibke Roland, Garbi Natalio, Ganss Ruth, Hämmerling Günter J, Arnold Bernd, Oelert Thilo
机构信息
*Division of Molecular Immunology (D050), German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
出版信息
Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15142-7. doi: 10.1073/pnas.0602622103. Epub 2006 Sep 28.
Abstract
In comparison with CD4+ regulatory T cells, the generation and function of immunomodulatory CD8+T cells is less well defined. Here we describe the existence of regulatory anti-Kb-specific CD8+ T cells that are rendered tolerant during neonatal life via antigen contact exclusively on keratinocytes. These regulatory T cells maintain tolerance during adulthood as they prevent Kb-specific graft rejection by naïve CD8+ T cells. Third-party immune responses remain unaffected. Up-regulation of TGF-beta1 and granzyme B in the regulatory CD8+ T cell population suggests the involvement of these molecules in common suppressive pathways shared with CD4+ regulatory T cells. In summary, CD8+ regulatory T cells can be induced extrathymically through antigen contact on neonatally accessible parenchymal cells and maintain tolerance throughout adult life.
摘要
与CD4+调节性T细胞相比，免疫调节性CD8+T细胞的产生和功能尚不太明确。在此，我们描述了调节性抗Kb特异性CD8+T细胞的存在，这些细胞在新生期通过仅在角质形成细胞上的抗原接触而产生耐受。这些调节性T细胞在成年期维持耐受状态，因为它们可防止幼稚CD8+T细胞介导的Kb特异性移植物排斥反应。第三方免疫反应不受影响。调节性CD8+T细胞群体中TGF-β1和颗粒酶B的上调表明这些分子参与了与CD4+调节性T细胞共有的常见抑制途径。总之，CD8+调节性T细胞可通过新生期可接触的实质细胞上的抗原接触在胸腺外诱导产生，并在成年期维持耐受。
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Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells.前沿：CD8+CD122+调节性T细胞产生白细胞介素-10以抑制CD8+T细胞的γ干扰素产生和增殖。
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