哮喘急性加重。3：发病机制。
Asthma exacerbations . 3: Pathogenesis.
作者信息
Wark P A B, Gibson P G
机构信息
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Locked Bag 1, Hunter Region Mail Centre, NSW 2310 Australia.
出版信息
Thorax. 2006 Oct;61(10):909-15. doi: 10.1136/thx.2005.045187.
Abstract
Asthma exacerbations are an exaggerated lower airway response to an environmental exposure. Respiratory virus infection is the most common environmental exposure to cause a severe asthma exacerbation. Airway inflammation is a key part of the lower airway response in asthma exacerbation, and occurs together with airflow obstruction and increased airway responsiveness. The patterns of airway inflammation differ according to the trigger factor responsible for the exacerbation. The reasons for the exaggerated response of asthmatic airways are not completely understood, but recent studies have identified a deficient epithelial type 1 interferon response as an important susceptibility mechanism for viral infection.
摘要
哮喘急性发作是下呼吸道对环境暴露的一种过度反应。呼吸道病毒感染是导致严重哮喘急性发作最常见的环境暴露因素。气道炎症是哮喘急性发作时下呼吸道反应的关键部分，与气流受限和气道反应性增加同时发生。根据导致急性发作的触发因素不同，气道炎症的模式也有所不同。哮喘气道过度反应的原因尚未完全明确，但最近的研究已确定上皮1型干扰素反应缺陷是病毒感染的一种重要易感性机制。
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