National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, Friendship Hospital, No.2, East Yinghua Road, Chaoyang District, 100029, Beijing, China.
Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Respir Res. 2023 Sep 26;24(1):231. doi: 10.1186/s12931-023-02504-4.
Asthma is a common, chronic inflammatory disease of the airways that affects millions of people worldwide and is associated with significant healthcare costs. Eosinophils, a type of immune cell, play a critical role in the development and progression of asthma. Eosinophil extracellular traps (EETs) are reticular structures composed of DNA, histones, and granulins that eosinophils form and release into the extracellular space as part of the innate immune response. EETs have a protective effect by limiting the migration of pathogens and antimicrobial activity to a controlled range. However, chronic inflammation can lead to the overproduction of EETs, which can trigger and exacerbate allergic asthma. In this review, we examine the role of EETs in asthma.
哮喘是一种常见的气道慢性炎症性疾病，影响着全球数以百万计的人，并且与巨大的医疗保健费用相关。嗜酸性粒细胞是一种免疫细胞，在哮喘的发生和发展中起着关键作用。嗜酸性粒细胞外诱捕网（EETs）是由 DNA、组蛋白和颗粒蛋白组成的网状结构，是嗜酸性粒细胞作为固有免疫反应的一部分形成并释放到细胞外空间的。EETs 通过限制病原体的迁移和抗菌活性在可控范围内发挥保护作用。然而，慢性炎症可导致 EETs 的过度产生，从而引发和加重过敏性哮喘。在这篇综述中，我们探讨了 EETs 在哮喘中的作用。
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