Ng K T, Man K, Sun C K, Lee T K, Poon R T, Lo C-M, Fan S-T
Centre for the Study of Liver Disease and Departments of Surgery, The University of Hong Kong, Queen Mary Hospital, L9-55, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China.
Br J Cancer. 2006 Oct 23;95(8):1050-5. doi: 10.1038/sj.bjc.6603399. Epub 2006 Sep 26.
Tumour recurrence and metastases of hepatocellular carcinoma (HCC) after hepatectomy are the major obstacles of long-term survival. The present study investigated the clinicopathological significance of a possible metastasis regulator Six1 in HCC patients who were undergone hepatectomy. Seventy-two pairs of RNA and 103 pairs of protein from tumour and adjacent nontumour liver tissues of HCC patients were examined. About 85 and 60% of HCC tumour tissues were found to overexpress Six1 mRNA and protein, respectively, compared with nontumour liver tissues. No Six1 protein was detected in HCC nontumour liver tissues and normal liver tissues. Increased Six1 protein expression in HCC patients was significantly correlated with pathologic tumour-node-metastasis (pTNM) stage (P=0.002), venous infiltration (P=0.004) and poor overall survival (P=0.0423). We concluded that Six1 is frequently overexpressed in HCC patients and elevated Six1 protein in HCC patients may be an indication of advanced stage and poor overall survival after hepatectomy.
肝癌肝切除术后的肿瘤复发和转移是长期生存的主要障碍。本研究调查了一种可能的转移调节因子Six1在接受肝切除术的肝癌患者中的临床病理意义。检测了72对肝癌患者肿瘤及癌旁非肿瘤肝组织的RNA和103对蛋白质。与非肿瘤肝组织相比，约85%和60%的肝癌肿瘤组织分别发现Six1 mRNA和蛋白质过表达。在肝癌非肿瘤肝组织和正常肝组织中未检测到Six1蛋白。肝癌患者中Six1蛋白表达增加与病理肿瘤-淋巴结-转移（pTNM）分期（P=0.002）、静脉浸润（P=0.004）及总体生存率差（P=0.0423）显著相关。我们得出结论，Six1在肝癌患者中经常过表达，肝癌患者中Six1蛋白升高可能提示肝切除术后处于晚期且总体生存率差。
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