Kong Jienan, Zhou Xianchun, Han Longzhe, Quan Chunji, Cui Xuelian, Lin Zhenhua
Department of Pathology, Medical College, Yanbian University, Yanji 133000, China.
Department of Internal Medicine, Yanbian University, Yanji 133000, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Feb;32(2):236-9.
To investigate the clinicopathological significance of ezrin and SIX1 overexpression in alpha fetoprotein (AFP)-negative hepatocellular carcinoma (HCC).
The EnVision immunohistochemical method was used to detect the protein expression of ezrin and SIX1 in the tumor tissues and corresponding adjacent normal liver tissues from 50 AFP-negative HCC patients. The correlations between the overexpression of ezrin and SIX1 and the prognosis of the patients with HCC were analyzed by Chi-square test and Spearman analysis.
The positive rates of ezrin and SIX1 protein expression in AFP-negative HCC tissues were 68.0% (34/50) and 60.0% (30/50), respectively, and they were significantly higher than the expression rates [38.0% (19/50) and 26.0% (13/50)] in adjacent normal liver tissues. Chi-square test showed that the expression of both ezrin and SIX1 proteins were related to TNM stage and lymphovascular infiltration, and Spearman analysis revealed a positive correlation between ezrin and SIX1 expression in AFP-negative HCC.
Both Ezrin and SIX1 proteins are highly expressed in AFP-negative HCC, and significantly related with the TNM stage and lymphovascular infiltration of patients with AFP-negative HCC. In addition, there is a positive correlation between ezrin and SIX1 expression in AFP-negative HCC.
探讨埃兹蛋白（ezrin）和SIX1在甲胎蛋白（AFP）阴性肝细胞癌（HCC）中过表达的临床病理意义。
采用EnVision免疫组化法检测50例AFP阴性HCC患者肿瘤组织及相应癌旁正常肝组织中ezrin和SIX1的蛋白表达。采用卡方检验和Spearman分析，分析ezrin和SIX1过表达与HCC患者预后的相关性。
AFP阴性HCC组织中ezrin和SIX1蛋白阳性率分别为68.0%（34/50）和60.0%（30/50），显著高于癌旁正常肝组织的表达率[38.0%（19/50）和26.0%（13/50）]。卡方检验显示，ezrin和SIX1蛋白表达均与TNM分期和淋巴管浸润有关，Spearman分析显示AFP阴性HCC中ezrin与SIX1表达呈正相关。
Ezrin和SIX1蛋白在AFP阴性HCC中均高表达，且与AFP阴性HCC患者的TNM分期和淋巴管浸润显著相关。此外，AFP阴性HCC中ezrin与SIX1表达呈正相关。
