Jones G C, Cortese D A, Neel H B
Dept of Otorhinolaryngology, Mayo Clinic, Rochester, MN 55905.
Ann Otol Rhinol Laryngol. 1990 Dec;99(12):941-4. doi: 10.1177/000348949009901202.
Hematoporphyrin derivative phototherapy (HpD-PT) has been successfully used to localize and treat superficial squamous cell cancers. Bleomycin sulfate is a glycopeptide antibiotic that has antineoplastic properties against squamous cell cancers. Because both HpD-PT and bleomycin chemotherapy are accepted forms of treatment for squamous cell cancer and their cytotoxicity is mediated by singlet oxygen and oxygen radicals, we studied the possibility of enhancing the response of solid tumors to HpD-PT by combining this modality with systemic bleomycin chemotherapy in a murine tumor model. Bleomycin did not enhance HpD-PT significantly. Also, we are not confident that HpD-PT alone or in combination with other agents can eradicate solid tumors; it certainly did not in this syngeneic murine tumor model.
血卟啉衍生物光疗法（HpD-PT）已成功用于浅表性鳞状细胞癌的定位和治疗。硫酸博来霉素是一种糖肽类抗生素，对鳞状细胞癌具有抗肿瘤特性。由于HpD-PT和博来霉素化疗都是治疗鳞状细胞癌的公认方法，且它们的细胞毒性是由单线态氧和氧自由基介导的，因此我们在小鼠肿瘤模型中研究了将这种治疗方式与全身博来霉素化疗相结合，以增强实体瘤对HpD-PT反应的可能性。博来霉素并未显著增强HpD-PT的效果。此外，我们不确定单独使用HpD-PT或与其他药物联合使用能否根除实体瘤；在这个同基因小鼠肿瘤模型中肯定无法根除。
