Phillip M J, Maximuke P P
Department of Microbiology and Biochemistry, University of Detroit School of Dentistry, Mich.
Oncology. 1989;46(4):266-72. doi: 10.1159/000226729.
A Chemiluminescent System (CLS), using a Peroxyoxalate chemiluminescent solution (PCs), together with Hematoporphyrin derivative (HpD) Photofrin II., were utilized in the treatment of transplanted mammary adenocarcinomas in C3H/HeJ female mice. Tumor bearing animals aged 2-4 months were divided into five groups; Group I was the control. Groups 2 and 4 compared the effectiveness of both reagents HpD and PCs which were administered by intratumor injections fractionated over a 96 hour period. Groups 3 and 5 compared the effectiveness of PCs alone. Tests of the PCs were conducted with and without the presence of luminescence. Fifty-three percent of the animals in Group 4 and 47% of the animals in Group 2 remained tumor free 120 days after the completion of treatment. Thirty percent of the animals in Groups 2 and 4 survived one year without tumor recurrence. The results of this study suggest that a chemical light system can be a viable alternative in Photodynamic Therapy (PDT) to laser light for the activation of HpD and treatment of cancer.
一种化学发光系统（CLS），使用过氧草酸酯化学发光溶液（PCs），并联合血卟啉衍生物（HpD）光卟啉II，用于治疗C3H/HeJ雌性小鼠移植性乳腺腺癌。2至4个月龄的荷瘤动物被分为五组；第一组为对照组。第二组和第四组比较了通过在96小时内分阶段瘤内注射给予的HpD和PCs这两种试剂的有效性。第三组和第五组比较了单独使用PCs的有效性。在有和没有发光的情况下对PCs进行了测试。治疗完成120天后，第四组53%的动物和第二组47%的动物无肿瘤。第二组和第四组30%的动物存活一年且无肿瘤复发。这项研究的结果表明，在光动力疗法（PDT）中，化学光系统可以作为激活HpD和治疗癌症的激光的可行替代方案。
