5-磷酸核糖-1-焦磷酸经非酶和酶促途径分解为1-磷酸核糖的过程。
The route of non-enzymic and enzymic breakdown of 5-phosphoribosyl 1-pyrophosphate to ribose 1-phosphate.
作者信息
Trembacz H, Jezewska M M
机构信息
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa.
出版信息
Biochem J. 1990 Nov 1;271(3):621-5. doi: 10.1042/bj2710621.
Abstract
Spontaneous decomposition of 5-phosphoribosyl 1-pyrophosphate at pH 5.5 was established to occur as follows: 5-Phosphoribosyl 1-pyrophosphate----5-phosphoribosyl 1,2-(cyclic)phosphate----ribose 1-phosphate----ribose Enzymic degradation of 5-phosphoribosyl 1-pyrophosphate by alkaline phosphatase from calf intestine and by acid phosphatases from potato and Aspergillus niger was found to proceed according to this pathway within the pH range 2.5-7.4 with accumulation of ribose 1-phosphate. In the case of alkaline phosphatase, Mg2+ ions inhibit the pyrophosphorolysis of 5-phosphoribosyl 1-pyrophosphate and stimulate the hydrolysis of ribose 1-phosphate.
摘要
已确定5-磷酸核糖1-焦磷酸在pH 5.5时的自发分解过程如下：5-磷酸核糖1-焦磷酸→5-磷酸核糖1,2-（环）磷酸→核糖1-磷酸→核糖。发现来自小牛肠的碱性磷酸酶以及来自马铃薯和黑曲霉的酸性磷酸酶对5-磷酸核糖1-焦磷酸的酶促降解在pH 2.5 - 7.4范围内按照此途径进行，并积累核糖1-磷酸。就碱性磷酸酶而言，Mg2 +离子抑制5-磷酸核糖1-焦磷酸的焦磷酸解，并刺激核糖1-磷酸的水解。
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