Krantz David, Hallahan Terrence, Ishack Stephanie, Macri V James, Macri James N
Research Division, NTD Laboratories, Huntington Station, NY 11746, USA.
Prenat Diagn. 2006 Dec;26(12):1137-41. doi: 10.1002/pd.1574.
To determine the association of free beta hCG and PAPP-A measured during first-trimester Down syndrome risk assessment with early pregnancy loss when blood is drawn prior to scheduled ultrasound.
Maternal dried blood samples were collected prior to the ultrasound exam for Down syndrome risk assessment. Free beta hCG and PAPP-A levels in 55 patients who experienced loss of pregnancy prior to their scheduled ultrasound appointment were compared to 6464 control pregnancies using logistic regression.
Low levels of free beta hCG and PAPP-A were associated with increased risk of early pregnancy loss. The detection rate of early pregnancy loss for a fixed 5% false-positive rate using free beta alone, PAPP-A alone and a combination of the two were 47, 36 and 49%, respectively.
Free beta hCG and PAPP-A can identify pregnancies at increased risk for early pregnancy loss. More studies are needed to determine whether further evaluation of these pregnancies prior to the scheduled ultrasound is warranted.
确定在孕早期进行唐氏综合征风险评估时，在预定超声检查前采血所检测的游离β-人绒毛膜促性腺激素（β-hCG）和妊娠相关血浆蛋白-A（PAPP-A）与早期妊娠丢失之间的关联。
在超声检查前采集孕妇干血样本以进行唐氏综合征风险评估。使用逻辑回归分析，将55例在预定超声检查前发生妊娠丢失的患者的游离β-hCG和PAPP-A水平与6464例对照妊娠进行比较。
游离β-hCG和PAPP-A水平低与早期妊娠丢失风险增加相关。对于固定的5%假阳性率，单独使用游离β-hCG、单独使用PAPP-A以及两者联合检测早期妊娠丢失的检出率分别为47%、36%和49%。
游离β-hCG和PAPP-A可识别早期妊娠丢失风险增加的妊娠。需要更多研究来确定是否有必要在预定超声检查前对这些妊娠进行进一步评估。
