FK506对BB大鼠自发性糖尿病的影响。
Effect of FK 506 on spontaneous diabetes in BB rats.
作者信息
Murase N, Lieberman I, Nalesnik M A, Mintz D H, Todo S, Drash A L, Starzl T E
机构信息
Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pennsylvania.
出版信息
Diabetes. 1990 Dec;39(12):1584-6. doi: 10.2337/diab.39.12.1584.
From days 30-120 after birth, 59 BB rats were treated with water (n = 20) or FK 506 in intragastric doses of 1 mg.kg-1.day-1 (n = 19) or 2 mg.kg-1.day-1 (n = 20). Diabetes developed in 75, 15, and 0% of the 3 groups, respectively. Animals protected from diabetes by FK 506 had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, and normal pancreatic insulin content. Forty-five to 75 days after stopping FK 506, approximately 75% of the rats that were diabetes free at 120 days remained so.
出生后30至120天期间，59只BB大鼠分别接受以下处理：用水处理（n = 20），或用剂量为1毫克·千克⁻¹·天⁻¹的FK 506进行灌胃处理（n = 19），或用剂量为2毫克·千克⁻¹·天⁻¹的FK 506进行灌胃处理（n = 20）。三组中糖尿病的发病率分别为75%、15%和0%。通过FK 506预防糖尿病的动物腹腔内葡萄糖耐量试验正常，组织病理学上几乎没有自身免疫性胰岛炎，胰腺胰岛素含量正常。停用FK 506后45至75天，在120天时未患糖尿病的大鼠中约75%仍保持无糖尿病状态。
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