FK506可预防BB大鼠的自发性糖尿病。
FK 506 prevents spontaneous diabetes in the BB rat.
作者信息
Murase N, Lieberman I, Nalesnik M, Mintz D, Todo S, Drash A L, Starzl T E
机构信息
Department of Surgery, University of Pittsburgh, Pennsylvania.
出版信息
Transplant Proc. 1991 Feb;23(1 Pt 1):551-5.
The BB rat is the experimental analogue of human juvenile diabetes mellitus. From 30 through 120 days after birth, 59 BB rats were treated with water (n = 20), or FK 506 in daily intragastric doses of 1 mg/kg (n = 19) or 2 mg/kg (n = 20). Diabetes developed in 75%, 15%, and 0% of the three groups. Animals protected from diabetes by FK 506, and killed in the nondiabetic state at 120 days had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, normal pancreatic insulin content, and immunocytochemical confirmation of islet insulin and glucagon content. Forty five to 75 days after stopping FK 506, about 3/4 of the animals who were diabetes free at 120 days have remained so. These results provide support for a clinical trial of FK 506 for recent onset diabetes.
BB大鼠是人类青少年糖尿病的实验模型。出生后30至120天，59只BB大鼠分别接受水（n = 20）、每日胃内给予1 mg/kg FK 506（n = 19）或2 mg/kg FK 506（n = 20）的处理。三组中糖尿病的发生率分别为75%、15%和0%。FK 506预防糖尿病的动物在120天时处于非糖尿病状态，其腹腔内葡萄糖耐量试验正常，组织病理学上几乎没有自身免疫性胰岛炎，胰腺胰岛素含量正常，胰岛胰岛素和胰高血糖素含量经免疫细胞化学证实正常。停用FK 506后45至75天，120天时未患糖尿病的动物中约3/4仍保持无糖尿病状态。这些结果为FK 506用于新发糖尿病的临床试验提供了支持。
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