Shi Jian-Hong, Wen Jin-Kun, Han Mei
Institute of Basic Medicine, Hebei Medical University, Hebei Laboratory of Medical Biotechnology, Shijiazhuang, China.
Sheng Li Ke Xue Jin Zhan. 2006 Jul;37(3):211-5.
Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a key role in vascular remodeling diseases, such as atherosclerosis, hypertension and restenosis. Recent researches have focused on the expression regulation of VSMC-specific marker genes and cytoskeleton organization in association with phenotypic modulation of VSMCs. Smooth muscle 22 alpha (SM22 alpha) is a novel differentiated VSMC marker, which is characterized by its smooth muscle tissue-specific and VSMC phenotype-specific expression pattern, and serves as an actin-association protein to participate in VSMC cytoskeleton organization and vascular remodeling. This article reviews recent advances in the characterization of SM22 alpha structure and its mechanism in VSMC cytoskeleton organization and vascular remodeling.
血管平滑肌细胞（VSMCs）的表型调节在诸如动脉粥样硬化、高血压和再狭窄等血管重塑疾病中起关键作用。最近的研究集中在与VSMCs表型调节相关的VSMC特异性标记基因的表达调控和细胞骨架组织方面。平滑肌22α（SM22α）是一种新型的分化型VSMC标记物，其特征在于其平滑肌组织特异性和VSMC表型特异性表达模式，并作为一种肌动蛋白结合蛋白参与VSMC细胞骨架组织和血管重塑。本文综述了SM22α结构特征及其在VSMC细胞骨架组织和血管重塑中的机制的最新进展。
