Mayer Amit, Erez Offer, Novack Lena, Bashiri Asher, Wiznitzer Arnon, Mazor Moshe
Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of Negev, Beer-Sheva, Israel.
Eur J Obstet Gynecol Reprod Biol. 2007 Aug;133(2):157-63. doi: 10.1016/j.ejogrb.2006.07.055. Epub 2006 Sep 28.
The objective was to determine the prevalence of maternal and perinatal complications among patients with rheumatologic diseases (RD) and to investigate the maternal risk factors for preeclampsia and preterm delivery among RD patients.
A retrospective population-based cohort study was conducted. The study group comprised women with RD; the control group comprised patients without RD. The obstetric and neonatal outcomes of the groups were compared, and the data were obtained from a computerized database.
During the study period, there were 179 deliveries by 125 women with RD. The prevalence of severe preeclampsia, chronic hypertension, pregestational diabetes, oligohydramnios, preterm deliveries and cesarean sections was significantly higher in the RD group than in the control group. Mean birth weight was significantly lower in the study group compared with the general population. Maternal RD was found to be an independent risk factor for preterm delivery and severe preeclampsia (OR 3.59; 95% CI: 2.52-5.11; OR 3.05; 95% CI: 1.44-6.45, respectively). The presence of chronic hypertension in patients with RD was found to be an independent risk factor for severe preeclampsia and preterm delivery (OR 12.2; 95% CI: 2.1-69.8; OR 3.8; 95% CI: 1.1-12.7, respectively).
Chronic hypertension is an independent risk factor for preterm delivery and severe preeclampsia among RD patients.
确定风湿性疾病（RD）患者中孕产妇及围产期并发症的患病率，并调查RD患者发生子痫前期和早产的孕产妇风险因素。
进行了一项基于人群的回顾性队列研究。研究组包括患有RD的女性；对照组包括无RD的患者。比较两组的产科和新生儿结局，并从计算机化数据库中获取数据。
在研究期间，125名患有RD的女性分娩了179例婴儿。RD组中重度子痫前期、慢性高血压、孕前糖尿病、羊水过少、早产和剖宫产的患病率显著高于对照组。与一般人群相比，研究组的平均出生体重显著更低。发现孕产妇RD是早产和重度子痫前期的独立危险因素（OR分别为3.59；95%CI：2.52 - 5.11；OR为3.05；95%CI：1.44 - 6.45）。发现RD患者中慢性高血压的存在是重度子痫前期和早产的独立危险因素（OR分别为12.2；95%CI：2.1 - 69.8；OR为3.8；95%CI：1.1 - 12.7）。
慢性高血压是RD患者早产和重度子痫前期的独立危险因素。
