Mohseni Mohammad G, Arasteh Saeid, Alizadeh Farshid
Department of Urology, Tehran University of Medical Sciences, Tehran, Iran.
Urology. 2006 Sep;68(3):505-7. doi: 10.1016/j.urology.2006.03.064.
To assess the efficacy of lubricating jelly instillation proximal to the upper ureteral calculi during lithotripsy on the prevention of retrograde stone displacement and the stone-free rate.
Thirty-four patients with upper ureteral calculi of less than 2 cm were randomized into two groups: jelly instillation (n = 16) and controls (n = 18). Ureteroscopy was performed using a 9.8F semirigid ureteroscope. A 5F ureteral stent was advanced beyond the stone. Lidocaine jelly (2 mL) was instilled, and lithotripsy was done with a Swiss Lithoclast. A 5F ureteral catheter was left in place for 24 hours, and patients were followed up at 24 hours with radiography of the kidneys, ureters, and bladder and at 2 weeks with intravenous urography.
Both groups were comparable in terms of mean age and stone size. Stone or stone fragment migration occurred in 12.4% of the treatment group and 44.4% of the controls, statistically significantly different (P = 0.046). The stone-free rate was 93.7% and 83.3% in the treatment and control groups, respectively. The rates did not improve after 2 weeks, and the difference was not statistically significant between the two groups (P = 0.384). The mean operative time was also comparable between the two groups.
Lidocaine jelly instillation proximal to the ureteral calculi during lithotripsy is an effective method to prevent retrograde stone displacement, but its effect on improving the stone-free rate was not significant in our study. Larger studies are needed to disclose more details about the efficacy of this method.
评估在输尿管上段结石碎石术中,于结石近端注入润滑凝胶对预防结石逆行移位及结石清除率的效果。
将34例输尿管上段结石直径小于2 cm的患者随机分为两组:凝胶注入组(n = 16)和对照组(n = 18)。使用9.8F半硬性输尿管镜进行输尿管镜检查。将一根5F输尿管支架管推进至结石上方。注入2 mL利多卡因凝胶,然后用瑞士碎石机进行碎石。留置一根5F输尿管导管24小时,术后24小时行肾脏、输尿管和膀胱造影随访,术后2周行静脉肾盂造影随访。
两组患者的平均年龄和结石大小具有可比性。治疗组结石或结石碎片移位发生率为12.4%,对照组为44.4%,差异有统计学意义(P = 0.046)。治疗组和对照组结石清除率分别为93.7%和83.3%。2周后结石清除率未提高,两组间差异无统计学意义(P = 0.384)。两组平均手术时间也具有可比性。
输尿管结石碎石术中在结石近端注入利多卡因凝胶是预防结石逆行移位的有效方法,但在本研究中其对提高结石清除率的效果不显著。需要开展更大规模的研究以进一步揭示该方法疗效的更多细节。