Jackson Andrew, Yorke Ellen D, Rosenzweig Kenneth E
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
Semin Radiat Oncol. 2006 Oct;16(4):260-8. doi: 10.1016/j.semradonc.2006.04.009.
We present a new method of reporting the results of radiotherapy protocols. The dose-volume atlas of complication incidence is a comprehensive and unbiased summary of the dose-volume exposures and complications occurring in patients after treatment. This new tool provides clear and systematic information about the safety of regions of dose-volume exposure previously treated that can be used when considering new treatments. Actuarial and model-dependent versions of the atlas are described. By using the raw data in the appropriate forms of the atlas, logistic regression, Kaplan-Meier, and Cox proportional hazards analysis can be performed, allowing for the independent calculation of dose-volume response. The data required are simple enough that provided compatible definitions of dose, volume, and complications are used, atlases from different protocols are potentially additive, facilitating the meta-analysis of inter-interinstitutional data. If this method were adopted as a standard for reporting the outcome of treatment protocols, a potentially synergistic increase in the utility of each protocol could result.
我们提出了一种报告放射治疗方案结果的新方法。并发症发生率的剂量-体积图谱是治疗后患者剂量-体积暴露和并发症情况的全面且无偏倚的总结。这个新工具提供了关于先前治疗的剂量-体积暴露区域安全性的清晰且系统的信息，在考虑新治疗时可以使用。描述了图谱的精算版本和基于模型的版本。通过以图谱的适当形式使用原始数据，可以进行逻辑回归、Kaplan-Meier分析和Cox比例风险分析，从而独立计算剂量-体积反应。所需数据足够简单，只要使用兼容的剂量、体积和并发症定义，来自不同方案的图谱就可能具有累加性，便于对机构间数据进行荟萃分析。如果将这种方法用作报告治疗方案结果的标准，可能会使每个方案的效用产生协同增加。
