Billiet C, Berard P, Rivoalan F, Neyra P, Gouillat C
Département de Chirurgie, Hôtel-Dieu, 69288 Lyon cedex 02, France.
Ann Chir. 2006 Dec;131(10):601-7. doi: 10.1016/j.anchir.2006.06.009. Epub 2006 Jul 5.
The treatment of locally recurrent rectal cancer (LRRC) remains a difficult and controversial issue. The aim of this study was to retrospectively assess the results of an univocal attitude associating resection of a priori resectable lesions using visceral excisions as required, without sacral excision, but including intra-operative radiotherapy (IORT).
Between 1989 and 1999, 32 patients underwent resection for LRRC. Twelve had previously undergone abdomino-perineal excision and 22 had received radiotherapy. Twenty-three patients underwent pelvic exenteration (total in 17, with rectus myocutaneous flap in 18). Twenty-five patients underwent IORT.
Three patients (9.3%) died in the early postoperative period and 11 experienced complications (37%). Resections were considered R0 in 6 patients, R1 in 21 patients and R2 in 5 patients. Five-year survival rates, overall and without disability, were respectively 12%, 12% and 5%. Median survivals, overall and without disability, were respectively 22 and 12 months.
Resection of LRRC remains a surgical challenge. It may achieve an average of one-year survival without disability, and hope for a few cures. Improvement of oncologic results might come from a more accurate patient selection.
局部复发性直肠癌(LRRC)的治疗仍然是一个困难且存在争议的问题。本研究的目的是回顾性评估一种明确态度的治疗结果,即根据需要采用脏器切除术切除先验可切除病变,不进行骶骨切除,但包括术中放疗(IORT)。
1989年至1999年间,32例患者接受了LRRC切除术。其中12例此前接受过腹会阴联合切除术,22例接受过放疗。23例患者接受了盆腔脏器清除术(17例为全盆腔脏器清除术,18例采用腹直肌肌皮瓣)。25例患者接受了术中放疗。
3例患者(9.3%)在术后早期死亡,11例出现并发症(37%)。6例患者的切除被认为是R0切除,21例为R1切除,5例为R2切除。总体和无残疾的五年生存率分别为12%、12%和5%。总体和无残疾的中位生存期分别为22个月和12个月。
LRRC的切除仍然是一项外科挑战。它可能实现平均一年的无残疾生存期,并有望治愈少数患者。肿瘤学结果的改善可能来自更准确的患者选择。