Quiñones-Jenab Vanya
Department of Psychology, Hunter College and Graduate School, City University of New York, New York, NY 10021, USA.
Brain Res. 2006 Dec 18;1126(1):200-3. doi: 10.1016/j.brainres.2006.08.109. Epub 2006 Sep 28.
Both preclinical and clinical studies have shown sexually dimorphic patterns in behavioral responses to cocaine in all phases of the cocaine addiction process (induction, maintenance, and relapse). Thus, a clear picture is emerging which suggests that the biological basis of sex-specific differences in cocaine addiction resides in the disparate regulation of the CNS by male and female gonadal hormones. This review discusses the role that gonadal hormones play in these sexually dimorphic patterns of behavioral responses to cocaine.
临床前和临床研究均表明,在可卡因成瘾过程的各个阶段(诱导、维持和复发),对可卡因的行为反应存在性别差异模式。因此,一幅清晰的图景正在浮现,这表明可卡因成瘾中性别特异性差异的生物学基础在于男性和女性性腺激素对中枢神经系统的不同调节。本综述讨论了性腺激素在这些对可卡因行为反应的性别差异模式中所起的作用。