Glaser B M
Center for Vitreoretinal Research, Wilmer Ophthalmological Institute, Baltimore, Maryland.
J Diabet Complications. 1990 Jul-Sep;4(3):108-12. doi: 10.1016/0891-6632(90)90049-b.
The process of neovascularization or new blood vessel formation is extraordinarily complex, requiring the successful coordination of numerous cellular and extracellular events. The ever increasing number of factors that can modulate events involved in neovascularization and the ability of some and possibly all of these factors to have different effects, depending upon the presence or absence of co-factors, require new hypotheses regarding the initiation and control of neovascularization. Each factor by itself is probably relatively meaningless, just as an individual number is in a combination used to open a lock. However, several factors occurring in a specific combination can unlock neovascularization. Different combinations may play a role in different disease states. Therefore, rather than classifying these substances as growth factors it may be more accurate to call them "extracellular modulating factors," or EMFs. The balance among these EMFs most likely varies during health and disease and in response to therapeutic intervention.
新生血管形成或新血管生成的过程极其复杂，需要众多细胞和细胞外事件成功协调。能够调节新生血管形成相关事件的因素数量不断增加，而且其中一些甚至可能所有这些因素会因辅助因子的存在与否而产生不同影响，这就需要有关新生血管形成起始和控制的新假说。每个因素本身可能相对无意义，就如同用于开锁的组合中的单个数字。然而，以特定组合出现的几个因素却能开启新生血管形成。不同组合可能在不同疾病状态中发挥作用。因此，与其将这些物质归类为生长因子，将它们称为“细胞外调节因子”（EMF）可能更准确。这些EMF之间的平衡很可能在健康和疾病期间以及对治疗干预的反应中发生变化。
