作用于DNA和RNA合成的试剂对聚（ADP-核糖）聚合酶活性的影响。
Influence of agents that act on DNA and RNA synthesis on the activity of poly(ADP-Rib) polymerase.
作者信息
Müller W E, Zahn R K
出版信息
Experientia. 1975 Sep 15;31(9):1014-5. doi: 10.1007/BF02326930.
PMID:170123
Abstract
The activity of poly(ADP-Rib) polymerase is enhanced in the presence of spermine and spermidine. Among the adenosine-like antibiotics tested, only formycin B and showdomycin cause an inhibition of the enzyme, which is competitive to NAD. The activity of poly(ADP-Rib) polymerase is not reduced by rifamycin, alpha-amanitin and 2-phenylethanol.
摘要
在精胺和亚精胺存在的情况下，聚（ADP - 核糖）聚合酶的活性会增强。在所测试的腺苷类似物抗生素中，只有间型霉素B和多氧霉素能抑制该酶，这种抑制作用对NAD具有竞争性。聚（ADP - 核糖）聚合酶的活性不会因利福霉素、α - 鹅膏蕈碱和2 - 苯乙醇而降低。
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