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铁饥饿会触发枯草芽孢杆菌的严谨反应，并诱导其合成用于产生杆菌肽的氨基酸。

Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis.

作者信息

Miethke Marcus, Westers Helga, Blom Evert-Jan, Kuipers Oscar P, Marahiel Mohamed A

机构信息

Fachbereich Chemie/Biochemie der Philipps-Universität Marburg, Marburg, Germany.

出版信息

J Bacteriol. 2006 Dec;188(24):8655-7. doi: 10.1128/JB.01049-06. Epub 2006 Sep 29.

DOI:10.1128/JB.01049-06
PMID:17012385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1698241/
Abstract

Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur). The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production.

摘要

细菌中的铁剥夺会导致受铁摄取调节因子（Fur）控制的基因去阻遏。目前对在基本培养基中生长的铁饥饿枯草芽孢杆菌细胞进行的微阵列分析揭示了对大量与严格反应调节相关的基因以及与杆菌肽合成必需途径相关的氨基酸生物合成相关基因的额外生理影响。

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Iron limitation induces SpoT-dependent accumulation of ppGpp in Escherichia coli.铁限制诱导大肠杆菌中由SpoT介导的鸟苷四磷酸（ppGpp）积累。
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