De Rose Robert, Sullivan Mark T, Dale C Jane, Kelleher Anthony D, Emery Sean, Cooper David A, Ramshaw Ian A, Boyle David B, Kent Stephen J
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.
Hum Vaccin. 2006 May-Jun;2(3):134-6. doi: 10.4161/hv.2940. Epub 2006 May 10.
Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 x 10(7)pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poorly immunogenic in humans. When adjusted for body surface area, the human dose studied was equivalent to a poorly immunogenic lower dose in monkeys. These data provide a rationale for guiding dosing in future trials of HIV vaccine technologies.
估算新型HIV疫苗的有效剂量具有挑战性。对DNA和鸡痘病毒HIV疫苗的剂量反应分析表明，1毫克DNA疫苗和5×10⁷蚀斑形成单位（pfu）的鸡痘病毒加强剂对猕猴具有免疫原性。然而，该剂量在人类中的免疫原性较差。按体表面积调整后，所研究的人类剂量相当于猕猴中免疫原性较差的较低剂量。这些数据为指导未来HIV疫苗技术试验中的剂量设定提供了理论依据。
