Baxter Alisa C, Lotspeich Linda J, Spiker Donna, Martin Jacquelin L, Grether Judith K, Hallmayer Joachim F
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5719, USA.
J Autism Dev Disord. 2007 May;37(5):976-82. doi: 10.1007/s10803-006-0217-8.
The etiology of autism is complex, consisting of unknown genetic and environmental factors. Previous studies have revealed that maternal age is increased in autism compared to controls, making it a possible risk factor. This study examined the effects of maternal age on autism severity using IQ as a measure of cognitive severity and selected subtests of the Child Behavior Checklist (CBCL) as measures of social severity. A sample of 154 subjects with autism spectrum disorders was obtained from the Stanford Neuropsychiatry/Pervasive Developmental Disorder (PDD) clinic. Results indicate that there is no relationship between IQ or selected CBCL subtests and maternal age, suggesting that maternal age does not influence the severity of autism as measured by these indicators.
自闭症的病因很复杂,由未知的遗传和环境因素组成。先前的研究表明,与对照组相比,自闭症患者的母亲年龄有所增加,这使其成为一个可能的风险因素。本研究以智商作为认知严重程度的衡量指标,并选择儿童行为检查表(CBCL)的子测试作为社会严重程度的衡量指标,来检验母亲年龄对自闭症严重程度的影响。从斯坦福神经精神病学/广泛性发育障碍(PDD)诊所选取了154名自闭症谱系障碍患者作为样本。结果表明,智商或所选的CBCL子测试与母亲年龄之间没有关系,这表明母亲年龄不会影响这些指标所衡量的自闭症严重程度。