Taravosh-Lahn Kereshmeh, Bastida Christel, Delville Yvon
Institute for Neuroscience and Psychology Department, University of Texas at Austin, Austin, TX 78712, USA.
Behav Neurosci. 2006 Oct;120(5):1084-92. doi: 10.1037/0735-7044.120.5.1084.
In male golden hamsters (Mesocricetus auratus), attack frequency decreases during puberty. As serotonin inhibits offensive responses in adult hamsters, it is hypothesized that the serotonin system becomes upregulated in the hypothalamus during puberty. This hypothesis was tested through acute treatment with fluoxetine, a serotonin reuptake inhibitor, as well as through analysis of serotonin innervation in specific brain areas. In adults, fluoxetine treatment inhibited aggressive behavior. In juveniles, high doses of fluoxetine only reduced offensive responses (i.e., frequency and repetition of attacks), whereas low doses enhanced them. Juveniles also showed a dose-specific maturation of attack targets. In addition, the density of serotonin innervation of the hypothalamus was 20% higher in adult hamsters compared with juveniles. On the basis of these data, it is proposed that the developing serotonergic system shapes the development of offensive behaviors in male golden hamsters.
在雄性金黄仓鼠（Mesocricetus auratus）中，攻击频率在青春期会降低。由于血清素会抑制成年仓鼠的攻击性反应，因此推测血清素系统在青春期时下丘脑会上调。通过使用血清素再摄取抑制剂氟西汀进行急性治疗以及分析特定脑区的血清素神经支配来验证这一假设。在成年仓鼠中，氟西汀治疗会抑制攻击行为。在幼年仓鼠中，高剂量的氟西汀只会降低攻击性反应（即攻击的频率和重复次数），而低剂量则会增强这些反应。幼年仓鼠还表现出攻击目标的剂量特异性成熟。此外，成年仓鼠下丘脑的血清素神经支配密度比幼年仓鼠高20%。基于这些数据，有人提出发育中的血清素能系统塑造了雄性金黄仓鼠攻击行为的发展。
