van de Kerkhof Peter C M
Department of Dermatology, Radboud University Nijmegen, Medical Center, Nijmegen, The Netherlands.
Dermatol Ther. 2006 Sep-Oct;19(5):252-63. doi: 10.1111/j.1529-8019.2006.00082.x.
Both in the topical and systemic treatment of psoriasis, retinoids are mainstays. In this chapter the history and modes of actions of retinoids are presented. Tazarotene and acitretin are the only retinoids that are available in both topical and systemic formulations. A more extensive description of their pharmacology, modes of action, indications and contraindications, clinical results, and treatment strategies will be presented. Finally, retinoid X receptor ligands and retinoic acid metabolism blocking agents will be introduced as potential future retinoid mimetics in psoriasis.
