在不同条件下饲养的近交系小鼠脑细胞的总RNA含量。
Total RNA content of brain cells of inbred mice reared under different conditions.
作者信息
Clausing P, Novakova V
机构信息
Central Institute of Microbiology and Experimental Therapy, Academy of Sciences, Jena, G.D.R.
出版信息
J Hirnforsch. 1990;31(4):429-31.
AB/Jena, DBA/2Jena, C57B1/6 Jena inbred mice and ABD2F1- and B6D2F4-hybrid mice either were reared communally and weaned at day 30 or were reared by isolated mothers and weaned at day 21 (I21). On day 50 the total RNA content of pyramidal brain cells of male offspring was determined by cytophotometry. The studied brain areas were the frontal pole of cerebral cortex (FCC) and the CA1 region of the dorsal hippocampus (DHI). The DBA, C57 and ABD2 mice had a reduced FCC and DHI RNA-content under I21-rearing. Under these conditions the AB strain has the highest RNA-content in both substrates. The results call for the awareness of possible genetic influences when studying the effects of environmental enrichment/impoverishing.
AB/耶拿、DBA/2耶拿、C57B1/6耶拿近交系小鼠以及ABD2F1和B6D2F4杂交小鼠，要么群居饲养并在30日龄断奶，要么由单独的母鼠饲养并在21日龄断奶（I21）。在50日龄时，通过细胞光度法测定雄性后代锥体脑细胞的总RNA含量。研究的脑区是大脑皮质额极（FCC）和背侧海马体CA1区（DHI）。在I21饲养条件下，DBA、C57和ABD2小鼠的FCC和DHI RNA含量降低。在这些条件下，AB品系在两种底物中的RNA含量最高。研究结果提醒我们，在研究环境丰富/匮乏的影响时，要意识到可能存在的遗传影响。
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