Völker Hans-Ullrich, Röper Gerhard, Sterk Jürgen, Willy Christian
Department of Pathology, Military Hospital, Ulm, Germany.
Wound Repair Regen. 2006 Sep-Oct;14(5):542-7. doi: 10.1111/j.1743-6109.2006.00161.x.
Pressure ulcers are frequently seen dermal lesions, but little is known about their pathophysiology. It is generally assumed that prolonged tissue pressure impairs blood circulation thus causing ischemic damage to tissue. Therefore, subcutaneous oxygen partial pressure was measured to confirm this hypothesis. In the past, various authors have conducted tests on healthy subjects to determine oxygen partial pressure transcutaneously during periods not exceeding 20 minutes. All found a decrease at susceptible sites, e.g., the sacrum. The present study was the first one to measure oxygen partial pressure subcutaneously above the sacrums of four test subjects during a period of 5 hours. In all cases, the values first decreased to a minimum of 37% of baseline before they returned to the initial values. This observation is in contradiction to former studies, which start from the assumption of critical ischemia due to interface pressure, measured on healthy volunteers too.
压疮是常见的皮肤损伤，但对其病理生理学知之甚少。一般认为，长时间的组织压力会损害血液循环，从而导致组织缺血性损伤。因此，测量皮下氧分压以证实这一假设。过去，许多作者对健康受试者进行了测试，以在不超过20分钟的时间内经皮测定氧分压。所有人都发现易感部位（如骶骨）的氧分压下降。本研究是首次在4名受试者的骶骨上方皮下测量5小时期间的氧分压。在所有情况下，这些值首先降至基线的最低值37%，然后才恢复到初始值。这一观察结果与以前的研究相矛盾，以前的研究也是基于对健康志愿者测量的界面压力导致临界缺血的假设。
