Sternitzky R, Kessler H, Mrowietz C, Pindur G, Jung F
Institute for Cardiovascular Research, Forststrasse 5, 01099 Dresden, Germany.
Clin Hemorheol Microcirc. 2002;27(3-4):185-91.
Previous studies demonstrated that naftidrofuryl increased the cutaneous and intramuscular tissue pO2 at rest. The presented open prospective pilot study is to investigate in apparently healthy subjects (n=12) whether naftidrofuryl also affects pO2 in situations of muscular stress. The pO2 is measured with a flexible probe in the anterior tibial muscle during treadmill exercise prior to and after one-week treatment with 100 mg of naftidrofuryl administered three times a day. The intake of naftidrofuryl proved to significantly affect the intramuscular partial oxygen pressure. With 38.6+/-22.9 mmHg, the pO2 is at rest already significantly (p<0.05), i.e., approx. 40% higher after one week of intake than before treatment (27.3+/-12.1 mmHg). This higher pO2 level is maintained during exercise. The higher the physical load, the larger the difference in pO2. While under naftidrofuryl treatment the measured pO2 values exhibit the tendency to increase during the first exercise phase (at a load of 3 km/h and a gradient 5 degree), the differences are even significant under higher physical stress (at 5 km/h and a gradient of 10 degree). With 33.9+/-12.0 mmHg the mean minimum pO2 determined at the higher load level still ranges above the basal pO2 measured before the start of naftidrofuryl treatment.
先前的研究表明，萘呋胺可提高静息状态下皮肤和肌肉组织的氧分压。本项开放前瞻性试验研究旨在调查萘呋胺对12名健康受试者在肌肉应激状态下的氧分压是否也有影响。在用萘呋胺（100毫克，每日三次）进行为期一周的治疗前后，通过柔性探头在跑步机运动期间测量胫前肌的氧分压。结果证明，萘呋胺的摄入对肌肉内的氧分压有显著影响。静息时的氧分压为38.6±22.9毫米汞柱，已显著升高（p<0.05），即摄入一周后的氧分压比治疗前（27.3±12.1毫米汞柱）高出约40%。运动期间，这一较高的氧分压水平得以维持。身体负荷越高，氧分压的差异越大。在萘呋胺治疗期间，在运动的第一阶段（负荷为3公里/小时，坡度为5度）测量的氧分压值呈上升趋势，在更高的身体应激状态下（5公里/小时，坡度为10度）差异更为显著。在较高负荷水平下测定的平均最低氧分压为33.9±12.0毫米汞柱，仍高于萘呋胺治疗开始前测得的基础氧分压。
