韩国人群中FAS和FASL基因多态性与肺癌风险
Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population.
作者信息
Park Sun Ha, Choi Jin Eun, Kim Eun Jin, Jang Jin Sung, Lee Won Kee, Cha Sung Ick, Kim Chang Ho, Kam Sin, Kim Dong Sun, Park Rang-Woon, Kim Young-Chul, Han Sung Beom, Jung Tae Hoon, Park Jae Yong
机构信息
Cancer Research Institute, School of Medicine, Kyungpook National University, Dong In 2Ga 101, Daegu 700-422, Republic of Korea.
出版信息
Lung Cancer. 2006 Dec;54(3):303-8. doi: 10.1016/j.lungcan.2006.09.002. Epub 2006 Oct 2.
BACKGROUND
The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis. Polymorphisms in the promoter region of the FAS (-1377G>A and -670A>G) and FASL (-844C>T) have been shown to alter the transcriptional activities of these genes. In order to evaluate the contribution of these polymorphisms to the risk of lung cancer, we carried out a case-control study in a Korean population.
METHODS
The FAS and FASL genotypes were determined in 582 lung cancer patients and 582 healthy control subjects who were frequency-matched for age and gender.
RESULTS
The FAS and FASL genotypes and the FAS haplotypes exhibited no apparent relationship with the risk of lung cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of lung cancer.
CONCLUSION
These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans.
背景
FAS和FASL系统在调节外源性凋亡途径中起重要作用，该信号通路的不当调节会导致肺癌发生。FAS启动子区域（-1377G>A和-670A>G）及FASL（-844C>T）的多态性已被证实会改变这些基因的转录活性。为评估这些多态性对肺癌风险的影响，我们在韩国人群中开展了一项病例对照研究。
方法
对582例肺癌患者和582例年龄及性别频率匹配的健康对照者进行FAS和FASL基因分型。
结果
FAS和FASL基因分型以及FAS单倍型与肺癌风险无明显关联。此外，FAS和FASL多态性在肺癌发生过程中无显著相互作用。
结论
这些结果表明，FAS的-1377G>A和-670A>G以及FASL的-844C>T多态性对韩国人患肺癌的易感性无显著影响。
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