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PLoS One. 2013;8(1):e53075. doi: 10.1371/journal.pone.0053075. Epub 2013 Jan 11.
3
Polymorphisms of the FAS and FASL genes and risk of breast cancer.FAS和FASL基因多态性与乳腺癌风险
Oncol Lett. 2012 Mar;3(3):625-628. doi: 10.3892/ol.2011.541. Epub 2011 Dec 28.
4
FASL-844 T/C polymorphism: a biomarker of good prognosis of breast cancer in the Tunisian population.FASL-844T/C 多态性：一种预测突尼斯人群乳腺癌预后的生物标志物。
Hum Immunol. 2012 Sep;73(9):932-8. doi: 10.1016/j.humimm.2012.06.001. Epub 2012 Jun 22.
5
Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians.在高加索人群中，血管紧张素转换酶、Nod 样受体 1、Toll 样受体 4、FAS/FASL 基因多态性与幽门螺杆菌诱导的癌前胃病变和胃癌的发生之间缺乏关联。
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Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.全基因组关联研究鉴定出中国人群食管鳞癌的三个新易感位点。
Nat Genet. 2011 Jun 5;43(7):679-84. doi: 10.1038/ng.849.
7
Fas and FasL polymorphisms are not associated with acute myeloid leukemia risk in Koreans.Fas 和 FasL 多态性与韩国人急性髓系白血病风险无关。
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8
Polymorphisms in promoter region of FAS and FASL gene and risk of cardia gastric adenocarcinoma.FAS 和 FASL 基因启动子区域多态性与贲门胃腺癌风险。
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[Genetic polymorphisms in STK15 and MMP-2 associated susceptibility to esophageal cancer in Mongolian population].[STK15和MMP-2基因多态性与蒙古族人群食管癌易感性的关系]
Zhonghua Yu Fang Yi Xue Za Zhi. 2009 Jul;43(7):559-64.
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中国北方人群中Fas/FasL基因多态性与食管癌易感性关联的定量评估

Quantitative assessment of the association between Fas/FasL gene polymorphism and susceptibility to esophageal carcinoma in a north Chinese population.

作者信息

Zhang Meijuan, Wu Cuiping, Li Baohuan, Du Wenjun, Zhang Chuanzhen, Chen Ziping

机构信息

Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.

出版信息

Cancer Med. 2016 Apr;5(4):760-6. doi: 10.1002/cam4.633. Epub 2016 Jan 27.

DOI:10.1002/cam4.633
PMID:26819081
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4831295/
Abstract

The case-control study aims to investigate the association of Fas and FasL genetic polymorphisms (Fas-670A/G (rs1800682), Fas-1377G/A (rs2234767) and FasL-844T/C (rs763110)) with esophageal carcinoma susceptibility in a north Chinese population. A total of 204 patients with esophageal carcinoma and 248 healthy controls were enrolled from Henan, China and genotyped by the polymerase chain reaction and restriction fragment length polymorphism method. There were no significant differences in distributions of their genotypes frequencies between patients and controls in Fas-670A/G, Fas-1377G/A and FasL-844T/C polymorphisms (P > 0.05). Stratified analysis showed that no significant association was found between esophageal carcinoma and gene polymorphisms of Fas-670 A/G, Fas-1377G/A, and FasL-844T/C (P > 0.05). Genetic polymorphisms in the death pathway genes Fas and FasL were not associated with risk of developing esophageal carcinoma in a north Chinese population.

摘要

这项病例对照研究旨在调查Fas和FasL基因多态性（Fas - 670A/G (rs1800682)、Fas - 1377G/A (rs2234767)和FasL - 844T/C (rs763110)）与中国北方人群食管癌易感性之间的关联。从中国河南招募了204例食管癌患者和248例健康对照，并采用聚合酶链反应和限制性片段长度多态性方法进行基因分型。在Fas - 670A/G、Fas - 1377G/A和FasL - 844T/C多态性方面，患者和对照之间的基因型频率分布没有显著差异（P > 0.05）。分层分析表明，食管癌与Fas - 670 A/G、Fas - 1377G/A和FasL - 844T/C基因多态性之间未发现显著关联（P > 0.05）。死亡途径基因Fas和FasL的基因多态性与中国北方人群患食管癌的风险无关。