Walter J, Allsopp T E, Bonhoeffer F
Max-Planck-Institut für Entwicklungsbiologie, Tübingen, FRG.
Trends Neurosci. 1990 Nov;13(11):447-52. doi: 10.1016/0166-2236(90)90097-t.
Axonal guidance in the retinotectal system and in spinal nerve segmentation is based on repulsion or inhibition. In both systems the membrane glycoprotein responsible for the guiding activity is capable of inducing growth cone collapse. We discuss two models of axonal guidance that correlate axonal guidance and growth cone collapse. The models are applicable to axon guidance by membrane-associated or diffusible stimuli, and are not based on preferential adhesion of axons to certain substrata.
视网膜顶盖系统和脊神经节段中的轴突导向基于排斥或抑制作用。在这两个系统中，负责导向活动的膜糖蛋白都能够诱导生长锥塌陷。我们讨论了两种将轴突导向与生长锥塌陷相关联的轴突导向模型。这些模型适用于由膜相关或可扩散刺激介导的轴突导向，且并非基于轴突对某些底物的优先黏附。
