Baek Seung Hoon, Piao Xiang Lan, Lee Un Jo, Kim Hyun Young, Park Jeong Hill
Research Institute of Pharmaceutical Sciences College of Pharmacy, Seoul National University, Seoul, Korea.
Biol Pharm Bull. 2006 Oct;29(10):2051-5. doi: 10.1248/bpb.29.2051.
Ginsenosides, the unique constituents and secondary metabolites of the Panax species, have been known to be the pharmacologically active ingredients of ginseng. Recently, our research group has developed a new processed ginseng, called Sun ginseng (SG), which has an increased amount of the red ginseng unique ginsenosides (RGUG). In our previous studies, this new processed ginseng reduced cisplatin-induced nephrotoxicity more than white ginseng in both in vitro and in vivo systems. In this study, we isolated and characterized active principles through activity-guided fractionation. Ginsenosides Rh4 and Rk3 significantly reduced the cisplatin-induced nephrotoxicity in LLC-PK1 cells in a dose-dependent manner. The mechanisms of function and structure-activity relationships with other ginsenosides remain for further investigation.
人参皂苷是人参属植物特有的成分和次生代谢产物，已知是人参的药理活性成分。最近，我们的研究小组开发了一种新的加工人参，称为太阳参（SG），其红参特有人参皂苷（RGUG）的含量有所增加。在我们之前的研究中，这种新的加工人参在体外和体内系统中比白参更能降低顺铂诱导的肾毒性。在本研究中，我们通过活性导向分级分离法分离并鉴定了活性成分。人参皂苷Rh4和Rk3以剂量依赖的方式显著降低了顺铂诱导的LLC-PK1细胞肾毒性。其功能机制以及与其他人参皂苷的构效关系仍有待进一步研究。
