Sawai Jun, Shiga Hirokazu
Department of Applied Bioscience, Faculty of Engineering, Kanagawa Institute of Technology, 1030 Shimo-Ogino, Atsugi, Kanagawa 243-0292.
Biocontrol Sci. 2006 Sep;11(3):125-8. doi: 10.4265/bio.11.125.
The antifungal activity of scallop-shell powder heated at 1000 degrees C for 1 h against Trichophyton was kinetically investigated and the possibility of applying the powder to the treatment of dermatophytosis was examined. The death rate of T. mentagrophytes NBRC5466 in the heated shell powder slurry increased with powder concentration, following first-order reaction kinetics. Elevated slurry temperatures increased both the apparent first-order death rate constant (k) and the dilution coefficient (n) representing the dependence of k on reagent concentration. The activation energy for the death of NBRC5466 was almost equal to that for bacteria, whereas the n value was much smaller than that for bacteria. In addition, the trial using heated shell powder treatment on feet showed the possibility of its application to treat dermatophytosis.
对在1000℃加热1小时的扇贝壳粉对毛癣菌的抗真菌活性进行了动力学研究，并考察了将该粉末应用于皮肤癣菌病治疗的可能性。在加热的贝壳粉浆液中，须癣毛癣菌NBRC5466的死亡率随粉末浓度的增加而增加，符合一级反应动力学。浆液温度升高既增加了表观一级死亡率常数（k），也增加了表示k对试剂浓度依赖性的稀释系数（n）。NBRC5466死亡的活化能几乎与细菌的活化能相等，而n值远小于细菌的n值。此外，在足部使用加热贝壳粉治疗的试验表明了其应用于治疗皮肤癣菌病的可能性。
