Gangane Nitin, Shivkumar Vitaladevuni B, Sharta Satish
Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha Maharashtra, India.
Acta Cytol. 2006 Sep-Oct;50(5):574-6. doi: 10.1159/000326019.
Amyloid in fine needle aspirates tends to be overlooked due to its rarity. It may appear at virtually any site and can be identified by special stains.
In a case of amyloidosis of the liver, where fine needle aspiration cytology was instrumental in making the primary diagnosis. Smears revealed normal hepatocytes and chronic inflammatory cells. Amorphous material (amyloid) was extensively present between compressed hepatocytic clusters. It stained pale green in Papanicolaou-stained preparations and reddish purple with Giemsa stain. This material was initially thought to be hyalinized granulomas. However, it was later confirmed to be amyloid by using Congo Red stain.
Whenever amorphous material is present in smears, a high index of suspicion for amyloid needs to be maintained.
细针穿刺抽吸物中的淀粉样蛋白因其罕见性往往被忽视。它几乎可出现在任何部位，可通过特殊染色进行识别。
在一例肝脏淀粉样变性病例中，细针穿刺细胞学检查对做出初步诊断起到了重要作用。涂片显示正常肝细胞和慢性炎症细胞。在压缩的肝细胞簇之间广泛存在无定形物质（淀粉样蛋白）。在巴氏染色的制片中它染成淡绿色，吉姆萨染色呈红紫色。这种物质最初被认为是透明变性的肉芽肿。然而，后来通过刚果红染色证实为淀粉样蛋白。
每当涂片中有无定形物质存在时，都需要高度怀疑淀粉样蛋白。
