关于帕金森病的神经保护疗法。
Concerning neuroprotective therapy for Parkinson's disease.
作者信息
Uitti R J, Wszolek Z K
机构信息
Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
出版信息
J Neural Transm Suppl. 2006(70):433-7. doi: 10.1007/978-3-211-45295-0_65.
Studying potential neuroprotective therapy for Parkinson's disease is conceptually problematic because of the heterogenous nature of the Parkinson's syndrome and complexities in operational definitions for neuroprotection. The current literature concerning neuroprotection provides no convincing evidence of any treatment as definitively neuroprotective in Parkinson's disease. Recent clinical trials and novel trial designs are reviewed that may identify meaningful therapy, resulting in maintenance of neurological function and quality of life for persons with Parkinson's disease.
由于帕金森综合征的异质性以及神经保护操作定义的复杂性，研究帕金森病的潜在神经保护疗法在概念上存在问题。目前有关神经保护的文献没有提供任何令人信服的证据表明有任何治疗方法在帕金森病中具有明确的神经保护作用。本文综述了近期的临床试验和新的试验设计，这些试验可能会确定有意义的治疗方法，从而维持帕金森病患者的神经功能和生活质量。
Zotero 插件