Kadowaki Kozo, Waguri Masako, Nakanishi Isao, Miyashita Yoshihiro, Nakayama Masahiro, Suehara Noriyuki, Funahashi Tohru, Shimomura Iichiro, Fujita Tomio
Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Izumi, Osaka 594-1101, Japan.
J Clin Endocrinol Metab. 2006 Dec;91(12):5090-4. doi: 10.1210/jc.2005-2846. Epub 2006 Oct 3.
Adiponectin (APN) concentration in umbilical cord serum is higher than that in adult serum. Except for the positive association between birth weight and cord APN concentration, little is known about the pathophysiological function of APN in fetal development.
The objective of this study was to evaluate the relationship of cord serum APN and IGF-I concentrations with the development of the fetoplacental unit.
Umbilical cord serum APN and IGF-I concentrations were measured in term singleton deliveries (n = 94). The association of cord APN and IGF-I concentrations was evaluated in relation to fetal weight, placental weight, and fetoplacental (F/P) weight ratio.
Mean concentrations and sd of APN and IGF-I were 36.1 +/- 14.0 microg/ml and 58.6 +/- 27.0 ng/ml, respectively. Cord APN concentration was positively associated with F/P weight ratio (r = 0.375, P < 0.001) as well as fetal weight (r = 0.389, P < 0.001) but not placental weight. Cord IGF-I concentration was positively associated with fetal weight (r = 0.405, P < 0.001) and placental weight (r = 0.400, P < 0.001) but not F/P weight ratio. In multiregression analysis, only APN concentration resulted in a significant determinant of F/P weight ratio among variables (beta = 0.376, P < 0.001).
In cord hyperadiponectinemia, fetuses tend to be disproportionately larger for their placental weight and vice versa in cord hypoadiponectinemia. APN is shown to be the first biomarker positively associated with F/P weight ratio.
脐带血清中脂联素（APN）浓度高于成人血清。除出生体重与脐带APN浓度呈正相关外，关于APN在胎儿发育中的病理生理功能知之甚少。
本研究旨在评估脐带血清APN和胰岛素样生长因子-I（IGF-I）浓度与胎儿-胎盘单位发育的关系。
测量了足月单胎分娩（n = 94）时脐带血清中的APN和IGF-I浓度。评估了脐带APN和IGF-I浓度与胎儿体重、胎盘重量以及胎儿-胎盘（F/P）重量比之间的关联。
APN和IGF-I的平均浓度及标准差分别为36.1±14.0微克/毫升和58.6±27.0纳克/毫升。脐带APN浓度与F/P重量比呈正相关（r = 0.375，P < 0.001）以及与胎儿体重呈正相关（r = 0.389，P < 0.001），但与胎盘重量无关。脐带IGF-I浓度与胎儿体重呈正相关（r = 0.405，P < 0.001）和与胎盘重量呈正相关（r = 0.400，P < 0.001），但与F/P重量比无关。在多元回归分析中，在各变量中只有APN浓度是F/P重量比的显著决定因素（β = 0.376，P < 0.001）。
在脐带高脂联素血症中，胎儿相对于胎盘重量往往不成比例地更大，反之在脐带低脂联素血症中则相反。APN被证明是第一个与F/P重量比呈正相关的生物标志物。
