Nelson Scott M, Freeman Dilys J, Sattar Naveed, Lindsay Robert S
Faculty of Medicine, University of Glasgow, Glasgow, UK.
Diabetes Care. 2008 Jun;31(6):1123-5. doi: 10.2337/dc07-2195. Epub 2008 Mar 13.
To assess the association of fetal hormones with placental growth and fetal weight-to-placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes.
We conducted a prospective study using umbilical venous blood samples taken at birth from 122 offspring of mothers with type 1 diabetes (OT1D) and 46 control subjects.
Placental weight (P = 0.009) and gestation-adjusted birth weight (P < 0.001) were increased in OT1D, but FPI was unaltered (P = 0.33). Placental weight correlated with birth weight (P < 0.001) and cord leptin (P < 0.001) in control subjects and OT1D, with further relationships with cord insulin, IGF-1, IGF-binding protein-3 (IGFBP-3), and triceps and subscapular thickness in OT1D. FPI was associated with adiponectin in both groups, even after adjustment for confounders.
Placental and fetal growth show a parallel increase in mothers with type 1 diabetes. The possible role of adiponectin in matching of fetal and placental growth merits further study.
评估妊娠合并母体糖尿病时胎儿激素与胎盘生长及胎儿体重与胎盘重量比指数（FPI）之间的关联。
我们进行了一项前瞻性研究，采用出生时采集的脐静脉血样本，样本来自122例1型糖尿病母亲的后代（OT1D）和46例对照受试者。
OT1D组的胎盘重量（P = 0.009）和经孕周调整的出生体重（P < 0.001）增加，但FPI未改变（P = 0.33）。在对照受试者和OT1D组中，胎盘重量与出生体重（P < 0.001）和脐带瘦素（P < 0.001）相关，在OT1D组中还与脐带胰岛素、胰岛素样生长因子-1（IGF-1）、胰岛素样生长因子结合蛋白-3（IGFBP-3）以及肱三头肌和肩胛下厚度有进一步的关系。两组中FPI均与脂联素相关，即使在调整混杂因素后也是如此。
1型糖尿病母亲的胎盘和胎儿生长呈现平行增加。脂联素在匹配胎儿和胎盘生长中的可能作用值得进一步研究。
