神经突生长因子（NOF）受体可能参与雏鸡发育中视网膜的轴突生长。
Possible involvement of neurite outgrowth factor (NOF) receptor in axonal outgrowth from developing chick retina.
作者信息
Taniura H, Hayashi Y, Miki N
机构信息
Department of Pharmacology I, Osaka University School of Medicine, Japan.
出版信息
Neurosci Res Suppl. 1990;13:S102-5. doi: 10.1016/0921-8696(90)90038-5.
We report that an 82-kDa membrane protein from chicken gizzard muscles is a neurite outgrowth factor (NOF)-receptor interacting with a domain for neurite-promoting activity of NOF. We found that an 82-kDa membrane protein in the developing chicken retina exhibited the same properties as those of gizzard muscles. The neuritic response of the retinal neurons to NOF increased in 6- and 8-day embryos, reaching a maximum level on the 8th-day and then rapidly decreased with aging. In parallel with this, the amount of NOF receptor in the retinas was maximal in 8- and 11-day embryos and thereafter decreased with aging. The results suggest that the failure in the neuritic response of the retinal neurons to NOF with aging is due to the decrease in NOF receptor.
我们报告称，来自鸡砂囊肌肉的一种82 kDa膜蛋白是一种神经突生长因子（NOF）受体，它与NOF的神经突促进活性结构域相互作用。我们发现，发育中的鸡视网膜中的一种82 kDa膜蛋白表现出与砂囊肌肉相同的特性。视网膜神经元对NOF的神经突反应在6日龄和8日龄胚胎中增加，在第8天达到最高水平，然后随着衰老迅速下降。与此同时，视网膜中NOF受体的量在8日龄和11日龄胚胎中最大，此后随着衰老而减少。结果表明，视网膜神经元对NOF的神经突反应随衰老而失败是由于NOF受体的减少。
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