Valdimarsdóttir Margrét, Hrafnsdóttir Agnes Hulda, Magnússon Páll, Gudmundsson Olafur O
Dept of Child and Adolesent Psychiatry, Landspítali University Hospital, Hringbraut, 101 Reykjavík, Iceland.
Laeknabladid. 2006 Sep;92(9):609-14.
ADHD is a well known psychiatric disorder that begins in childhood and frequently persists into adulthood. In the last decade numerous studies have shown the importance of genetic factors in the etiology of ADHD. However other etiological factors seem to be involved. The aim of this study was to examine the frequency of some possible etiological factors for ADHD in Icelandic children diagnosed with ADHD. The study is descriptive.
The participants were 196 children referred for suspected ADHD to the outpatient unit of the Department of Child and Adolescent Psychiatry, Landspitali University Hospital during a 2 year period 1998-1999. The participants had either ICD-10 or DSM-IV hyperkinetic disorder and/or ADHD and the information was obtained from patient case notes. Information provided by parents in a questionnaire concerning health in pregnancy and the perinatal period was retrospectively analysed.
The main results show statistically significant increased risk for ADHD associated with several factors such as low birthweight, young age of the mother at the time of the child's birth and Caesarean section, compared with reference groups such as mean values in all of the community. Other factors such as birthweight, alcohol or tobacco use in pregnancy, use of medication in pregnancy or vacuum extraction did not show statistically significant association with ADHD.
The results indicate as some studies from other countries have suggested that an association exists between a number of factors in pregnancy, delivery and perinatal period and ADHD, even though there is still not enough evidence to confirm definite etiological factors.
注意缺陷多动障碍(ADHD)是一种广为人知的精神疾病,始于童年,且常常持续至成年。在过去十年中,大量研究表明遗传因素在ADHD病因学中具有重要作用。然而,其他病因似乎也与之相关。本研究的目的是调查冰岛被诊断为ADHD的儿童中一些可能的病因因素的出现频率。该研究为描述性研究。
研究对象为1998年至1999年这两年间被转诊至Landspitali大学医院儿童与青少年精神病科门诊疑似患有ADHD的196名儿童。这些参与者患有ICD - 10或DSM - IV多动障碍和/或ADHD,相关信息来自患者病历。对父母在问卷中提供的有关孕期和围产期健康的信息进行回顾性分析。
主要结果显示,与所有社区的平均值等参照组相比,低出生体重、孩子出生时母亲年龄较小以及剖宫产等几个因素与ADHD相关,且具有统计学意义上的显著风险增加。其他因素,如出生体重、孕期饮酒或吸烟、孕期用药或真空吸引,与ADHD未显示出统计学意义上的显著关联。
结果表明,正如其他国家的一些研究所表明的,孕期、分娩和围产期的一些因素与ADHD之间存在关联,尽管仍没有足够的证据来证实明确的病因因素。