Waeber B
Division de physiopathologie clinique, CHUV, 1011 Lausanne.
Rev Med Suisse. 2006 Sep 13;2(78):2055-8.
Aldosterone plays a pivotal role in sodium and water homeostasis, in particular in patients with heart failure or high blood pressure. These medications, when used on top of a standard therapy, improve the outcome of patients with heart failure and are also effective in lowering blood pressure of hypertensive patients. The major risk associated with the use of these antagonists is hyperkalemia, which can be prevented in avoiding their prescription in patients with impaired renal function. Eplerenone has the advantage, compared with spironolactone, to be better tolerated in terms of "hormonal" adverse effects.
醛固酮在钠和水平衡中起关键作用，尤其是在心力衰竭或高血压患者中。这些药物在标准治疗基础上使用时，可改善心力衰竭患者的预后，对降低高血压患者的血压也有效。使用这些拮抗剂的主要风险是高钾血症，对于肾功能受损的患者避免使用这些药物可预防高钾血症。与螺内酯相比，依普利酮的优势在于在“激素”不良反应方面耐受性更好。
