Fomenko L A, Lomaeva M G, Bezlepkin V G, Gaziev A I
Radiats Biol Radioecol. 2006 Jul-Aug;46(4):431-5.
The F1-progeny of BALB/c male mice chronically exposed to low-dose gamma-radiation (0.1; 0.25 and 0.5 Gy; dose rate 0.01 Gy/day) as well as the F1-progeny of females exposed to acute X-radiation (0.5; 1.0 and 2.0 Gy; dose rate 0.1 Gy/min) shown the significant elevated micronuclei frequencies in bone marrow erythrocytes, as compared to the F1-progeny of unirradiated males and females. The increase in the micronuclei frequency in the F1-progeny was determined by the dose of irradiation of parents. The values of elevated micronuclei frequency in the F1-progeny of chronically irradiated males and acutely irradiated females for a dose of 0.5 Gy were comparable. The micronuclei frequencies in the F1-progeny of irradiated females and males for this dose were in 1.5 and in 1.6 times higher than ones in the F1-progeny of unirradiated mice correspondingly. The results suggest the possibility of transfer of genome instability from irradiated parents to the somatic cells of the F1-progeny via non-lethally damaged germ cells of parents.
长期暴露于低剂量γ辐射（0.1、0.25和0.5 Gy；剂量率0.01 Gy/天）的BALB/c雄性小鼠的F1代，以及暴露于急性X辐射（0.5、1.0和2.0 Gy；剂量率0.1 Gy/分钟）的雌性小鼠的F1代，与未受辐射的雄性和雌性小鼠的F1代相比，其骨髓红细胞中的微核频率显著升高。F1代微核频率的增加取决于亲代的辐射剂量。对于0.5 Gy的剂量，长期受辐射雄性和急性受辐射雌性的F1代中微核频率升高的值相当。对于该剂量，受辐射雌性和雄性的F1代中的微核频率分别比未受辐射小鼠的F1代高1.5倍和1.6倍。结果表明，基因组不稳定性有可能通过亲代非致死性受损的生殖细胞从受辐射亲代转移到F1代的体细胞中。
