[两代雌性Wistar大鼠在胎儿生殖系统发育的着床期接受小剂量照射后对后代的影响及其第二代后代的生殖功能]
[Consequences for posterity of two generations of an irradiation pregnant from females rats Wistar in small doses during a bookmark of reproduction system of fetuses development of posterity of the second generation and it reproduction function].
作者信息
Palyga G F, Chibisova O F
出版信息
Radiats Biol Radioecol. 2006 Jul-Aug;46(4):494-7.
With the purpose of study of consequences for development and reproduction functions of posterity of the second generation from females rats Wistar of a total unitary gamma-irradiation in dozes 0.25; 0.5 and 1 Gy (capacity of a doze 0.03 sGy/s) on 10th day of pregnancy (the period of the onset of fetuses reproduction system development) is investigated more than 630 females, 1400 with the age of 19th days, and about 3200 young rats. The revealed deviations(rejections) in development of posterity of two generations parents, antenatal irradiated in not sterilizing dozes, in he period of a beginning of formation of reproduction system, them a variety at different dozes of radiating influence, shown as at posterity of the irradiated mothers, and fathers, testify about instability genoms in a line of generations requiring the account and acceptance of necessary measures for preservation normal genofund.
为研究在妊娠第10天（胎儿生殖系统开始发育的时期）对Wistar雌性大鼠进行0.25；0.5和1 Gy剂量（剂量率0.03 sGy/s）的全身一次性γ射线照射对第二代后代发育和生殖功能的影响，对630多只雌性大鼠、1400只19日龄大鼠和约3200只幼鼠进行了研究。在生殖系统开始形成的时期，对两代亲代进行非绝育剂量的产前照射，所发现的后代发育偏差（异常），其在不同辐射剂量影响下的多样性，在受照射的母亲和父亲的后代中均有体现，证明了在代际间基因组的不稳定性，这需要考虑并采取必要措施来保存正常的基因库。
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