Jouyban A, Khoubnasabjafari M, Chan H K, Acree W E
Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Iran.
Pharmazie. 2006 Sep;61(9):789-92.
Applicability of a solution model for calculating solubility of amino acids in binary aqueous-organic solvent mixtures at various temperatures was shown. The accuracy of the proposed model was evaluated by computing mean percentage deviation (MPD) employing available solubility data of amino acids in binary solvents at various temperatures from the literature. The overall MPD (+/- SD) for correlation of solubility data was 16.5 +/- 8.8%. In addition, the equations calculating solubility of amino acids in binary solvent mixtures at a fixed temperature was revisited.
结果表明，一种溶液模型适用于计算不同温度下氨基酸在二元水 - 有机溶剂混合物中的溶解度。通过利用文献中不同温度下氨基酸在二元溶剂中的可用溶解度数据计算平均百分比偏差（MPD），对所提出模型的准确性进行了评估。溶解度数据相关性的总体MPD（±标准差）为16.5±8.8%。此外，还重新审视了计算固定温度下氨基酸在二元溶剂混合物中溶解度的方程。
