通过二烷基锌活化实现酮硅烯醇醚的自由基三氟甲基化反应。
Radical trifluoromethylation of ketone silyl enol ethers by activation with dialkylzinc.
作者信息
Mikami Koichi, Tomita Yuichi, Ichikawa Yoshiyuki, Amikura Kazutoshi, Itoh Yoshimitsu
机构信息
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan.
出版信息
Org Lett. 2006 Oct 12;8(21):4671-3. doi: 10.1021/ol0611301.
PMID:17020274
Abstract
[reaction: see text] The radical trifluoromethylation of ketone silyl enol ethers gave alpha-CF(3) ketones in good yields with wide scope of the ketonic substrates including acyclic ketones and cyclopentanone. The use of dialkylzinc to activate the silyl enol ethers is the key to the efficient radical trifluoromethylation.
摘要
[反应：见正文] 酮硅烯醇醚的自由基三氟甲基化反应能以良好的产率得到α-三氟甲基酮，酮底物范围广泛，包括无环酮和环戊酮。使用二烷基锌活化硅烯醇醚是高效自由基三氟甲基化反应的关键。
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