噬菌体B30溶素的内肽酶和糖苷酶活性
Endopeptidase and glycosidase activities of the bacteriophage B30 lysin.
作者信息
Baker John R, Liu Chengbao, Dong Shengli, Pritchard David G
机构信息
Department of Biochemistry & Molecular Genetics, MCLM 552, University of Alabama at Birmingham, 1530 3rd Ave. S, Birmingham, AL 35294-0005, USA.
出版信息
Appl Environ Microbiol. 2006 Oct;72(10):6825-8. doi: 10.1128/AEM.00829-06.
Abstract
Synthetic peptides corresponding to portions of group B streptococcal peptidoglycan were used to show that the endopeptidase activity of bacteriophage B30 lysin cleaves between D-Ala in the stem peptide and L-Ala in the cross bridge and that the minimal peptide sequence cleaved is DL-gamma-Glu-Lys-D-Ala-Ala-Ala. The only glycosidase activity present is that of N-acetyl-beta-D-muramidase.
摘要
与B族链球菌肽聚糖部分相对应的合成肽被用于表明噬菌体B30溶素的内肽酶活性在茎肽中的D-丙氨酸和交联桥中的L-丙氨酸之间裂解，并且裂解的最小肽序列是DL-γ-谷氨酸-赖氨酸-D-丙氨酸-丙氨酸-丙氨酸。仅存在的糖苷酶活性是N-乙酰-β-D-胞壁酸酶的活性。
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