Kohl Thomas
German Center for Fetal Surgery and Minimally-Invasive Therapy, Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany.
Curr Opin Anaesthesiol. 2004 Aug;17(4):315-21. doi: 10.1097/01.aco.0000137090.37484.88.
Since the early 1990s, advances in endoscopic equipment and the commercial availability of micro-catheters, mini-balloons, tiny laser fibers and other ingenious tools have set the trend toward the development of minimally invasive fetoscopic surgical techniques for the treatment of some congenital malformations that progress in severity over the course of gestation and may destroy entire organ systems of the unborn. The purpose of this review is to provide a state-of-the-art overview of these new procedures for the anesthesiologist.
Procedures like diagnostic fetoscopies, laser coagulation of inter-twin placental vascular connections in twin-twin transfusion syndrome, fetal tracheal balloon occlusion in diaphragmatic hernia, laser perforation of posterior urethral valves, vocal cord division in congenital high-airway obstruction syndrome and most recently even coverage of spina bifida aperta can be performed entirely percutaneously using minimally invasive fetoscopic techniques. Careful selection of anesthetic methods and intensive maternal monitoring by the anesthesiology team are paramount to the success of these procedures, particularly in hemodynamically unstable fetuses or procedures that employ gas insufflation of the amniotic cavity.
An increasing spectrum of congenital malformations can be treated by fetoscopic surgery. Compared to open fetal surgery, fetoscopic surgery results in significantly less maternal trauma. Like the open procedures, the efficacy of the fetoscopic procedures to improve fetal outcome over postnatal treatment strategies will have to be assessed in further studies under close supervision of committees for human research.
