Campiotti L, Grandi A M, Biotti M G, Ultori C, Solbiati F, Codari R, Venco A
Dipartimento di Medicina Clinica Università dell'Insubria, Varese, Italy.
Am J Hematol. 2007 Mar;82(3):231-3. doi: 10.1002/ajh.20797.
We describe an extremely rare case of megakaryocytic blast crisis as first presentation of chronic myeloid leukemia. The patient had a very high platelet count and developed an ischemic stroke with seizures. She was treated with hydroxyurea, platelet apheresis, ARA-C, and idarubicin in order to obtain a prompt reduction of thrombocytosis and then with imatinib 600 mg/die PO. The therapy induced a complete hematological remission with a resolution of neurological signs within 4 weeks.
我们描述了一例极为罕见的以巨核细胞原始细胞危象为首发表现的慢性髓性白血病病例。该患者血小板计数极高，并发生了伴有癫痫发作的缺血性中风。为迅速降低血小板增多症，她接受了羟基脲、血小板单采、阿糖胞苷和伊达比星治疗，随后口服伊马替尼600mg/天。治疗在4周内诱导了完全血液学缓解，神经症状也得以缓解。
